High-density oligonucleotide arrays
WebOn high-density oligonucleotide microarrays, DNA oligonucleotides are synthesized directly on the microarray using ultraviolet masks and photoactivated chemistry. 30 … Web1 de dez. de 1996 · Hacia, J., Brody, L., Chee, M. et al. Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two–colour fluorescence analysis. Nat Genet 14 , 441–447 (1996 ...
High-density oligonucleotide arrays
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WebAlthough oligonucleotide probes are often used in "spotted" microarrays, the term "oligonucleotide array" most often refers to a specific technique of manufacturing. … http://scgc.genetics.ucla.edu/sites/default/files/publications/2006%20Advancement%20in%20characterization%20of%20genomic%20alterations%20for%20improved%20diagnosis%20treatment%20and%20prognostics%20in%20cancer.pdf
WebAbstract. Motivation: High-density oligonucleotide arrays (GeneChip, Affymetrix, Santa Clara, CA) have become a standard research tool in many areas of biomedical … WebHigh-density oligonucleotide expression arrays are a widely used microarray platform. Affymetrix GeneChip arrays dominate this market. An important distinction between the GeneChip and other technologies is that on GeneChips, multiple short probes are used to measure gene expression levels.
Webple high density oligonucleotide arrays, it is important to re-move sources of variation between arrays of non-biological origin. Normalization is a process for reducing this varia-tion. It is common to see non-linear relations between ar-rays and the standard normalization provided by Affymetrix does not perform well in these situations. WebHigh density SNP arrays help scientists identify patterns of allelic imbalance. These studies have potential prognostic and diagnostic uses. Because LOH is so common in …
WebWe have developed an approach in which sequence information is used directly to design high–density, two–dimensional arrays of synthetic oligonucleotides. The GeneChip® probe arrays are made using spatially patterned, light–directed combinatorial chemical synthesis, and contain up to hundreds of thousands of different oligonucleotides on a small glass …
WebAn approach in which sequence information is used directly to design high–density, two–dimensional arrays of synthetic oligonucleotides is developed, which have been … the problem with bullying in schoolsWeb22 de jan. de 2003 · Motivation: When running experiments that involve multiple high density oligonucleotide arrays, it is important to remove sources of variation between arrays of non-biological origin. Normalization is a process for reducing this variation. signal gold newsWeb19 de set. de 2003 · High-density oligonucleotide arrays (1, 2) have revolutionized the study of gene expression.The technology enables researchers to detect and quantify tens of thousands of transcripts in a single experiment and has become a standard for the discovery of gene functions, drug evaluation, pathway dissection, and classification of clinical … signal generators and waveform generatorsWeb1 de dez. de 1996 · We have developed an approach that is based on hybridization to small, high-density arrays containing tens of thousands of synthetic oligonucleotides. The … signalgorithm.sha1withrsaWeb1 de jan. de 2002 · The leading arrays in the category of high-density oligonucleotide arrays are manufactured by Affymetrix and utilize the combinatorial synthesis principle. 9 The arrays are designed by using a light-directed chemical synthesis process that creates a series of photolithographic masks to define chip exposure sites, followed by specific … the problem with bullyingWebWe have developed an approach that is based on hybridization to small, high-density arrays containing tens of thousands of synthetic oligonucleotides. The arrays are … the problem with brandy melvilleWeb24 de jul. de 2015 · The methods for preparing DNA chips combine photochemistry and photolithography with solid-phase DNA synthesis chemistry to generate a high-density oligonucleotide probe array in situ [6,7,8]. These two-dimensional arrays containing hundreds or thousands of oligonucleotide probes provide a powerful DNA sequence … the problem with book banning