Dichloromethylene diphosphonate
WebIn mice administered with liposome-entrapped dichloromethylene diphosphonate, which depletes Kupffer cells, the size and the number of zymosan-induced granulomas in the liver were smaller than in untreated mice. The number of macrophage precursors, as detected by the monoclonal antibodies for macrophage precursors, increased after zymosan ... WebLiposomes containing the drug dichloromethylene diphosphonate (Cl2MDP) can eliminate phagocytic cells, such as macrophages, when injected in vivo. In this paper we report that Cl2MDP-containing liposomes have been used experimentally to determine the extent to which cutaneous macrophages participate …
Dichloromethylene diphosphonate
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WebThe daily subcutaneous administration of (dichloromethylene)diphosphonate (clodronate) to 3-day-old normal inbred Wistar-Furth rats for 30 days produces osteopetrotic bone … WebJun 22, 2005 · Background: Alveolar macrophages play an important role during the development of acute inflammatory lung injury. In the present study, in vivo alveolar macrophage depletion was performed by intratracheal application of dichloromethylene diphosphonate-liposomes in order to study the role of these effector cells in the early …
WebIn this study, we demonstrated that tracheal insufflation of liposome-encapsulated dichloromethylene diphosphonate (Cl2MDP-liposome) selectively depleted AMs in … WebDichloromethylene diphosphonate (MDPCl2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to lysosomes, …
WebExplore the latest full-text research PDFs, articles, conference papers, preprints and more on EAE. Find methods information, sources, references or conduct a literature review on EAE WebDMDP is ingested by phagocytic cells when entrapped in liposomes. Once phagocytized the liposomal membranes are digested and the drug is released into the cell and is ready for action. In vitro, even low doses of liposome-entrapped DMDP caused an significant reduction in cell numbers.
WebJul 30, 2012 · A single intra-articular injection of liposomes encapsulating the drug dichloromethylene diphosphonate (CL 2 MDP) in the mouse knee joint caused selective elimination of synovial lining cells. Depletion of cells occurred within a few days as evidenced by light microscopic, electron microscopic and immunohistochemical studies.
WebRats received a single intravenous injection with liposome-encapsulated dichloromethylene diphosphonate (C12MDP). This treatment resulted in the … rcvs disciplinary hearings rvnWebDes jeunes rats mâles (70–90g) ont été traités pendant dix jours avec 1) l’un des trois diphosphonates suivants: l’éthane-1-hydroxy-1,1-diphosphonate disodique (EHDP), le dichlorométhylène diphosphonate disodique (Cl 2 MDP) ou le méthane-1-cyclohéxyl-1-hydroxy-1,1-diphosphonate disodique (MCHDP), 2) de la calcitonine porcine. simulating speckle with mathematicaWebLiposome-encapsulated dichloromethylene diphosphonate (clodronate) is known to deplete macrophages. We examined the effect of clodronate on xenoreactive antibody production and xenograft rejection. Hamster cardiac grafts were transplanted into Lewis rats. Clodronate (4 mL/kg) was injected intravenously on the day before transplantation. rcvs code of conduct supporting guidance 15WebNov 1, 1984 · Outre leur action remarquable dans la maladie osseuse de Paget, les diphosphonates sont très efficaces dans le traitement des hypercalcémies dont l'origine osseuse est presque toujours essentielle. Dans les hypercalcémies malignes, l'EHDP, le CL2 MDP et l'APD, les trois diphosphonates testés chez l'homme font chuter la calcémie … rcvs controlled drugs prescriptionWebSep 1, 1996 · Dichloromethylene diphosphonate (MDPCl 2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to … simulating rocket exhaust in blenderWebSigma-Aldrich. 233183. Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem. A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. simulating sexual selection appWebDaily administration of dichloromethylene diphosphonate (Cl2MDP) to (C57BL/6 X DBA/2) F1 hybrid mice, from two days of age (10 mg of P/kg body weight), resulted in a … simulating reaction rate by dft