WebPatients with poor-risk leukemia have a high relapse rate despite allogeneic transplant. We report on the phase-2 trial of an intensified allogeneic transplant regimen whose aim was tolerable toxicity and durable remission. Study patients (n=30) had unfavorable first remission cytogenetics, progress … WebSpecifically, 1,000 g of cumulative exposure was considered the cutoff. “But that just doesn’t hold up any more,” he said, “because some patients will take smaller or larger daily amounts. Risk depends on the balance of …
ADRIAMYCIN (DOXOrubicin HCl) for Injection - Food and …
WebA number of risk factors may predispose a patient to cardiotoxicity. These are: cumulative dose (anthracyclines, mitomycin); total dose administered during a day or a course … WebThe most important risk factor for late cardiac toxicity is cumulative anthracycline dose. The associated incidence of HF is about 3%–5% with a doxorubicin cumulative dose of 400 mg/m2, and 18%–48% with a cumulative dose of 700 mg/m2. ... and symptoms of CHF may also occur at lower doses. Additional risk factors for anthracycline ... esb services limited
Cardiotoxicity of chemotherapeutic agents: incidence, treatment …
WebMar 19, 2014 · The cumulative oxaliplatin dose, time of infusion, and the existence of peripheral neuropathy prior to the initiation of chemotherapy rank among the most important triggers of chronic OXAIPN genesis. 80 In addition to these well-known risk factors, recent evidence from a large homogeneous series of colorectal cancer patients showed that ... WebMay 23, 2024 · However, despite an established dose-dependent association, there is interpatient variability in risk for CHF for exposure to anthracycline at any dose, such that clinical variables alone yield moderate predictive power in detecting CHF. 25,26 The pathophysiology of cardiotoxicity is unclear, but it is thought to be mediated by the … WebMar 26, 2024 · Older patients have increased risk of toxicity from chemotherapy. Current prediction tools do not provide information on cumulative risk. Patients aged ≥ 70 years with solid cancer were ... fingersoft news