WebNov 15, 2024 · Clinical trials have demonstrated that T regs can prevent and treat GVHD, without increasing the risk of relapse and infection (Guo et al., 2024). CD6, a costimulatory receptor is expressed on T cells including pathogenic T eff cells at high levels (CD6 high ), while Tregs are CD6 low. WebThe CD6-ALCAM pathway plays an integral role in T cell activation, differentiation, proliferation, and trafficking, and increased levels of CD6 are associated with pathogenic T cell responses. Thus, the CD6-ALCAM pathway is a potential contributor to disease pathogenesis and presents itself as a potential therapeutic target.
(PDF) The CD6/ALCAM pathway promotes lupus nephritis via T …
WebThe encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). WebJun 30, 2024 · The CD6 signaling pathway is only partially known and includes the activation of MAPK , and recruitment of Syntenin-1 and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76) . Recently, CD6 … excel szintfelmérő
Equillium to Present New Data and Insights on the CD6-ALCAM
WebJan 4, 2024 · CD6 blockade in models of spontaneous lupus and immune-complex glomerulonephritis revealed significant decreases in immune cells, inflammatory … WebThe CD6-ALCAM pathway: D Age 53.55 (15.6) 56.00 (18.6) 0.74 D 0.0 C • CD6 is a co-stimulatory receptor on T-cells and certain innate lymphoid cells that binds 0 C BMI 28.10 (3.7) 27.27 (7.2) 0.74 activated leukocyte cell adhesion molecule (ALCAM) on antigen presenting cells and -0.5 FEV1% 76.67 (17.5) 71.87 (23.8) 0.6 WebDriving Directions to Tulsa, OK including road conditions, live traffic updates, and reviews of local businesses along the way. excel szkolenie vba